Actively Recruiting
Long-term Graft Patency Outcomes of LIMA-LAD Post-CABG Surgery Based on iFR Measurements
Led by Prakash Punjabi · Updated on 2023-11-21
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the relationship between pre-operative intracoronary physiology measurements (iFR) and the success of bypass grafts in patients with multi-vessel coronary artery disease undergoing coronary artery bypass grafting (CABG) surgery. It is a proof of concept observational study involving between 28 and 100 patients conducted at a single center. The study seeks to establish if using iFR can better predict graft patency compared to traditional visual assessment methods during coronary angiograms. Patients scheduled for elective first-time CABG surgery will have iFR measurements taken during invasive coronary angiography before their operation. They will then undergo standard CABG surgery as part of their care. The study includes follow-up assessments with echocardiography at 3 months and computed tomography coronary angiography (CTCA) at 12 months to evaluate graft patency and heart function. Quality of life questionnaires will also be completed at 3 and 12 months. During the study, participants will be monitored for early graft failure through clinical symptoms and major cardiovascular events. Researchers will track outcomes such as myocardial infarction, stroke, repeat interventions, and death up to 12 months after surgery. Echocardiography at 3 months and CTCA at 12 months will provide detailed imaging data to assess the grafts. Quality of life and clinical data will be collected during clinic visits, with total participation lasting at least one year.
CONDITIONS
Brief Title
iFR Guided Coronary Artery Bypass Grafting Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age of 25 to 80 years
- Willing to participate and able to understand, read and sign the informed consent form before elective CABG surgery
- Undergoing isolated first-time elective CABG surgery
- Available pre-operative angiography data with iFR measurements done during the pre-operative angiography
You will not qualify if you...
- Emergency CABG surgery
- Ejection fraction 40% or less
- Severe valvular heart disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day to hospital discharge
Participants undergo coronary artery bypass grafting surgery (CABG) as part of standard care after pre-operative invasive coronary angiography with iFR measurements.
1 hospital stay visit
Duration - Up to 3 months
Participants have echocardiography and complete quality of life questionnaires to assess heart function and wellbeing.
1 visit at 3 months
Duration - Up to 12 months
Participants undergo computed tomography coronary angiography (CTCA) and complete quality of life questionnaires to assess graft patency and health status.
1 visit at 12 months
Trial Site Locations
Total: 1 location
1
Imperial College Healthcare NHS Trust - Hammersmith Hospital
London, Greater London, United Kingdom, W12 0HS
Actively Recruiting
Research Team
P
Prakash P Punjabi, MBBS,MCh,FRCS,FFST,FESC,FCCP
P
Panagiotis G Kyriazis, BSc, MRes
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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