Study of iFR Measurements to Improve Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery

What this Trial Is About

This research aims to evaluate the relationship between pre-operative intracoronary physiology measurements iFR and the success of bypass grafts in patients with multi-vessel coronary artery disease undergoing coronary artery bypass grafting CABG surgery. It is a proof of concept observational study involving between 28 and 100 patients conducted at a single center. The study seeks to establish if using iFR can better predict graft patency compared to traditional visual assessment methods during coronary angiograms. Patients scheduled for elective first-time CABG surgery will have iFR measurements taken during invasive coronary angiography before their operation. They will then undergo standard CABG surgery as part of their care. The study includes follow-up assessments with echocardiography at 3 months and computed tomography coronary angiography CTCA at 12 months to evaluate graft patency and heart function. Quality of life questionnaires will also be completed at 3 and 12 months. During the study, participants will be monitored for early graft failure through clinical symptoms and major cardiovascular events. Researchers will track outcomes such as myocardial infarction, stroke, repeat interventions, and death up to 12 months after surgery. Echocardiography at 3 months and CTCA at 12 months will provide detailed imaging data to assess the grafts. Quality of life and clinical data will be collected during clinic visits, with total participation lasting at least one year.

iFR Guided Coronary Artery Bypass Grafting Surgery