Actively Recruiting
IH, Brain Health, and T2D
Led by Darren P Casey · Updated on 2026-03-13
80
Participants Needed
1
Research Sites
144 weeks
Total Duration
On this page
Sponsors
D
Darren P Casey
Lead Sponsor
A
American Diabetes Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).
CONDITIONS
Official Title
IH, Brain Health, and T2D
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Age is 60 and 85 years of age
- Documented Type 2 diabetes (for diabetic group)
- Scoring 26 or higher on the MoCA test
You will not qualify if you...
- Diagnosis of type 2 diabetes less than 1 year prior to enrollment (for diabetic group)
- HbA1c less than 6.5% or greater than 10.0% (for diabetic group)
- Body mass index greater than 40 kg/m2
- Incident cardiovascular events in the last year such as heart attack or stroke
- Symptomatic coronary artery disease and/or heart failure
- Uncontrolled hypertension
- Obstructive sleep apnea
- Pulmonary disease
- Dementia
- Renal impairment with creatinine clearance (eGFR) less than 60 ml/min
- Smoking or history of smoking within past one year
- Diagnosis of diabetes (Type 1 or Type 2) for nondiabetic group
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
D
Darren Casey, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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