Actively Recruiting
IMA402 T Cell-Engaging Receptor Molecule (TCER®) in Recurrent and/or Refractory Solid Tumors
Led by Immatics Biotechnologies GmbH · Updated on 2025-11-18
145
Participants Needed
24
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the safety, tolerability and anti-tumor activity of IMA402 in patients with recurrent and/or refractory solid tumors. Primary objectives: * To determine the maximum tolerated dose and/or recommended dose for extension for IMA402 (Phase I) * To characterize the safety and tolerability of IMA402 (Phase I/II) * To evaluate anti-tumor activity of IMA402 (Phase II) Secondary objectives: * To evaluate the initial anti-tumor activity of IMA402 (Phase I) * To evaluate anti-tumor activity of IMA402 (Phase II) * To describe the PK of IMA402 (Phase I/II)
CONDITIONS
Official Title
IMA402 T Cell-Engaging Receptor Molecule (TCER®) in Recurrent and/or Refractory Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years old or older
- Patients with a confirmed advanced and/or metastatic solid tumor
- Patients who have received or are not eligible for all standard-of-care treatments
- Measurable disease according to RECIST 1.1
- Confirmed HLA status
- ECOG Performance Status of 0 to 1
- Adequate baseline blood, liver, and kidney function with acceptable coagulation status
You will not qualify if you...
- Other active cancers requiring treatment or that may affect trial outcomes (ongoing anti-hormonal treatment allowed)
- Pregnant or breastfeeding patients
- History of allergic reactions to IMA402 components or rescue medications without alternative treatments
- Severe or uncontrolled medical conditions that pose safety risks or interfere with the trial
- Patients with active brain metastases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
Universitaetsklinikum Heidelberg AöR
Heidelberg, Baden-Wurttemberg, Germany, 69120
Actively Recruiting
2
Universitaetsklinikum Mannheim GmbH
Mannheim, Baden-Wurttemberg, Germany, 68167
Actively Recruiting
3
Universitaetsklinikum Ulm AöR
Ulm, Baden-Wurttemberg, Germany, 89081
Actively Recruiting
4
Universitaetsklinikum Erlangen AöR
Erlangen, Bavaria, Germany, 91054
Actively Recruiting
5
Klinikum Nürnberg
Nuremberg, Bavaria, Germany, 90419
Actively Recruiting
6
Universitaetsklinikum Regensburg
Regensburg, Bavaria, Germany, 93053
Actively Recruiting
7
Universitaetsklinikum Wuerzburg AöR
Würzburg, Bavaria, Germany, 97080
Actively Recruiting
8
Justus-Liebig-Universitaet Giessen
Giessen, Hesse, Germany, 35392
Actively Recruiting
9
Philipps-Universitaet Marburg
Marburg, Hesse, Germany, 35043
Actively Recruiting
10
Elbe Kliniken Stade- Buxtehude Elbe Klinikum Buxtehude gGmbH
Buxtehude, Lower Saxony, Germany, 21614
Actively Recruiting
11
Universitaetsklinikum Bonn AöR
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
12
Marien Hospital Duesseldorf GmbH
Düsseldorf, North Rhine-Westphalia, Germany, 40479
Actively Recruiting
13
KEM I Evang. Kliniken Essen-Mitte gGmbH
Essen, North Rhine-Westphalia, Germany, 45136
Actively Recruiting
14
Universitaetsklinikum Essen AöR
Essen, North Rhine-Westphalia, Germany, 45147
Actively Recruiting
15
Johannes Wesling Klinikum Minden
Minden, North Rhine-Westphalia, Germany, 32429
Actively Recruiting
16
Universitaet Muenster
Münster, North Rhine-Westphalia, Germany, 48149
Not Yet Recruiting
17
Klinikum Chemnitz gGmbH
Chemnitz, Saxony, Germany, 09116
Actively Recruiting
18
Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
Dresden, Saxony, Germany, 01307
Actively Recruiting
19
University Of Leipzig
Leipzig, Saxony, Germany, 04103
Actively Recruiting
20
Universitaetsklinikum Magdeburg AöR
Magdeburg, Saxony-Anhalt, Germany, 39120
Actively Recruiting
21
Antoni von Leeuwenhoek- Netherlands Cancer Institute
Amsterdam, North Holland, Netherlands, 1066 CX
Actively Recruiting
22
Leiden Universitair Medisch Centrum
Leiden, South Holland, Netherlands, 2333 ZA
Actively Recruiting
23
Universitair Medisch Centrum Groningen
Groningen, Netherlands, 9713 GZ
Actively Recruiting
24
Universitair Medisch Centrum Utrecht
Utrecht, Netherlands, 3584 CX
Actively Recruiting
Research Team
I
Immatics Biotechnologies GmbH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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