Image-Based Prediction of Ventricular Tachycardia Events in Post-Myocarditis Patients: an International Multicenter Case-control Study

What this Trial Is About

Ventricular arrhythmias are often linked to structural heart diseases such as myocardial infarction, myocarditis, and non-ischemic cardiomyopathies. This research explores the role of scar tissue in the heart, particularly in patients who have had myocarditis, using advanced cardiac magnetic resonance imaging to analyze scar patterns and predict arrhythmia risk. The study aims to improve risk assessment beyond the current standard based on left ventricular ejection fraction, focusing on patients without previous arrhythmia signs. The study is observational and compares patients who experience sudden cardiac death or sustained ventricular arrhythmias to those who do not, analyzing heart scar characteristics through imaging data. Researchers will evaluate scar mass, border zone channels, and other tissue features obtained from cardiac MRI performed at least six months after myocarditis diagnosis. The goal is to better predict arrhythmia risk and refine implantable cardioverter-defibrillator (ICD) therapy recommendations. Participants will undergo cardiac magnetic resonance imaging and clinical follow-up for up to two years to monitor for arrhythmic events or sudden cardiac death. Researchers will collect data on heart function and scar tissue features, including advanced imaging markers. Outcomes include the incidence of sudden cardiac death, sustained ventricular tachycardia, and appropriate ICD therapies. Safety, consent, and feasibility will be ensured throughout the study period ending in December 2026.

Image-Based Prediction of Ventricular Tachycardias in Post-Myocarditis Patients: an International Multicenter Case-control Study