Actively Recruiting
Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy
Led by Jonsson Comprehensive Cancer Center · Updated on 2026-03-30
30
Participants Needed
1
Research Sites
192 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial studies mechanisms of resistance to 177-lutetium prostate specific membrane antigen (177Lu-PSMA) radioligand therapy using image-guided biopsies in patients with castrate-resistant prostate cancer that had spread to other places in the body (metastatic). Diagnostic procedures, such as image guided biopsies, may help in learning how well 177Lu-PSMA works to kill tumor cells and allow doctors to plan better treatment.
CONDITIONS
Official Title
Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Volunteer patient
- Histologically confirmed prostate cancer
- Eligible for 177Lu-PSMA-617 under expanded access protocol or approved trial
- PET/CT shows lymph node or soft tissue metastases suitable for image-guided biopsy
- Platelet count greater than 75,000/ul within 14 days before biopsy
- Prothrombin time (PT), INR, and partial thromboplastin time (PTT) less than 1.5 times institutional upper limit within 14 days before biopsy
- Patients on warfarin, aspirin, or other anticoagulants eligible if they can safely stop anticoagulation one week before biopsy
- Conversion to low molecular weight heparin before biopsy allowed with agreement among treating physician, radiologist, and principal investigator
You will not qualify if you...
- Significant congenital or acquired bleeding disorders such as von Willebrand's disease or acquired bleeding factor inhibitors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
A
Ankush Sachdeva
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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