Actively Recruiting
Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2026-02-13
20
Participants Needed
1
Research Sites
539 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Principal Investigator's (PI) working hypothesis is that the PI can utilize the high predictive value of 18F-DCFPyl PSMA to identify clinically significant tumors in patients who will undergo brachytherapy, as well as areas which are uninvolved or contain only clinically insignificant disease. In the PI's clinical trial, the uninvolved regions (as defined by combined PET-MR-biopsy data) will not be targeted and receive only fall-off dose, which we have shown to be associated with reductions in toxicity.
CONDITIONS
Official Title
Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of adenocarcinoma of the prostate
- Performance status less than 2
- Clinical stage T1c to T2a, Nx or N0, Mx or M0
- Gleason score 6 to 7 cancer
- Prostate volume under 60 cc (MRI value used if MRI and ultrasound differ)
- International Prostate Symptom Score (IPSS) of 20 or less
- Ability to undergo 18F-DCFPyl PSMA PET scan before treatment
- Signed consent form specific to this study before registration
You will not qualify if you...
- Prior pelvic radiation therapy
- Major medical or psychiatric illness that would prevent completing treatment or interfere with follow-up
- Implanted device blocking fluoroscopy visibility of implanted seeds
- Metallic implants, claustrophobia not manageable with medication, or contraindications to MRI
- History of other cancer diagnosed within the past 3 years
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
SKCCC at Johns Hopkins
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
D
Daniel Song, MD
CONTACT
D
Dana Kaplin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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