Actively Recruiting
Image-Guided Gynecologic Brachytherapy
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2025-12-18
54
Participants Needed
1
Research Sites
624 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research is being done to evaluate multimodality imaging, including magnetic resonance imaging-guided therapy (MRT), as a possible treatment for gynecologic cancers. The therapy takes place in the Department of Radiation Oncology at the Johns Hopkins SKCCC. The purpose of this study is to investigate the ability of MRI to successfully guide the placement of the brachytherapy applicator necessary to treat participants' gynecologic cancer. The Investigators want to see if the use of MRI will do a better job of assessing the tumor at the time of brachytherapy than the routinely used CT scan. The Investigators also want to determine if the use of MRI will enable doctors to reduce the radiation dose received by the body during the process of treating the tumor.
CONDITIONS
Official Title
Image-Guided Gynecologic Brachytherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must have confirmed carcinoma by tissue or cell analysis
- Eligible cancer types include carcinoma of the cervix (Stage I-IVA or vaginal recurrence), uterus (Stage IIIB with vaginal involvement, inoperable, or vaginal recurrence), vagina (Stage I-IVA or vaginal recurrence), vulva (Stage I-IVA or recurrence), or urethra as determined by the doctor
- Patients who are candidates for internal implantation without MR guidance are eligible
- Prior radiation or chemotherapy treatment is allowed
- Age must be over 18 years
- Life expectancy must be greater than 6 months
- ECOG performance status less than 2 or acceptable by doctor
- MRI of the pelvis or PET-CT scan within 4 months before enrollment
- Ability to understand and willing to sign informed consent
You will not qualify if you...
- Uncontrolled illnesses such as active infections, symptomatic heart failure, unstable angina, irregular heart rhythm, or psychiatric/social conditions limiting study compliance
- Absolute neutrophil count below 500 at enrollment
- History of metal in the head or eyes
AI-Screening
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Trial Site Locations
Total: 1 location
1
The SKCCC at Johns Hopkins
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
S
Shirley DiPasquale, R.N.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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