Study of MRI-Guided Brachytherapy for Treating Gynecologic Cancers Using Advanced Imaging to Improve Radiation Therapy Safety and Effectiveness

What this Trial Is About

Researchers are evaluating the use of magnetic resonance imaging MRI to guide brachytherapy treatment in gynecologic cancers such as cervical, uterine, vaginal, vulvar, and bladder cancers. This study aims to determine if MRI can more accurately assess tumors during brachytherapy compared to the commonly used CT scans, potentially improving treatment precision and reducing radiation exposure to healthy tissues. The goal is to improve how doctors plan radiation doses and reduce treatment-related side effects. The study involves using MRI-guided brachytherapy, where MRI scans help precisely place the radiation applicator to target the tumor. Investigators will compare radiation doses to organs at risk during MRI-based planning versus standard CT-based planning. The study will assess radiation dose thresholds that may cause toxicity and compare toxicity rates at 6 months, 1 year, and 2 years after treatment to improve future dose recommendations. Participants will undergo MRI scans to guide their brachytherapy treatment and will be monitored for treatment-related side effects and tumor control over time. Researchers will measure changes in radiation dosing over 3 years and track toxicity rates, local tumor failure, and survival at various intervals up to 2 years. The total participation duration includes treatment and follow-up monitoring to evaluate the safety and effectiveness of MRI-guided brachytherapy.

Image-Guided Gynecologic Brachytherapy