Actively Recruiting
Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)
Led by The University of Texas Health Science Center at San Antonio · Updated on 2026-02-05
150
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
W
Wellcome Leap Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is testing a new treatment called IR-TMS (image-guided, robot navigated transcranial magnetic stimulation) to see if it can help people who drink too much alcohol to reduce the amount they drink. Participants will be placed into one of three groups, each receiving a slightly different version of this treatment. The study involves going through a few sessions of IR-TMS, having brain scans (MRI), providing blood and urine samples, and answering questions about their drinking and mental health. These activities are part of the study and aren't usually part of regular treatment for alcohol use. IR-TMS is different from regular treatments like therapy or medication because it uses magnetic fields to target specific parts of the brain. The goal is to see if this treatment can help reduce the urge to drink. There are other options, like sticking with therapy or medication, which are less intense but have been used for a longer time.
CONDITIONS
Official Title
Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Two self-reported heavy drinking episodes (>4 drinks for men, >3 drinks for women) or more than 13 drinks in the last 14 days at screening
- Phosphatidylethanol (PEth) level greater than 20 ng/mL at baseline
- Diagnosis of current moderate to severe Alcohol Use Disorder according to DSM-5
- Ability to attend all study appointments
- Fluent in English
You will not qualify if you...
- Current diagnosis of moderate or severe substance use disorder other than AUD, cannabis, or nicotine
- Unable to provide informed consent
- Alcohol withdrawal-related seizure or hospitalization within the past 12 months
- Currently enrolled in treatment for Alcohol Use Disorder
- Psychiatric or medical conditions making participation unsafe, including bipolar disorder, schizophrenia, or schizoaffective disorder
- History or signs of serious medical or neurological illness including seizure disorders
- History of traumatic brain injury with loss of consciousness for 20 minutes or more
- Liver enzymes more than 5 times the normal range
- Pregnant females
- Presence of metal objects in the body unsafe for MRI or that may affect brain imaging quality (e.g., surgical clips, pacemakers, metal implants)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Be Well Institute, University of Texas Health Science Center - Department of Psychiatry & Behavioral Sciences
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
B
Brett C Ginsburg, PhD
CONTACT
T
Tara Wright, PhD, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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