Actively Recruiting
Imaging Biomarkers in ALS
Led by University of Minnesota · Updated on 2025-12-02
30
Participants Needed
1
Research Sites
839 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to determine if we are able to find one or more biomarkers of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) using magnetic resonance imaging (MRI) scans at different levels, 3 tesla (3T) and 7 tesla (7T). A biomarker is a measurable characteristic that can be used as an indicator of a particular disease state. Identifying biomarkers of a disease can lead to a better understanding of the disease as well as improved treatments. This study will enroll patients with ALS, PLS, and healthy controls.
CONDITIONS
Official Title
Imaging Biomarkers in ALS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 to 75 years of age inclusive
- Willing and able to give signed informed consent approved by the Institutional Review Board (IRB)
- Clinical diagnosis of possible, laboratory-supported probable, probable, or definite ALS based on modified El Escorial criteria (for ALS patients)
You will not qualify if you...
- Diagnosis of other neurodegenerative diseases such as Parkinson's disease or Alzheimer's disease
- Clinically significant unstable medical illness within the last 30 days, including unstable angina or advanced cancer
- Inability to undergo MRI scanning due to inability to remain still for more than 30 minutes, claustrophobia, presence of paramagnetic substances or pacemakers, weight over 300 lbs, or inability to lie flat comfortably for 75-90 minutes
- Requires assistance to ambulate or climb stairs, unless likely able to participate in MRI screening 12 months after enrollment based on investigator opinion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
V
Valerie Ferment
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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