Actively Recruiting
Imaging Biomarkers of FOG Response to DBS
Led by Medical University of South Carolina · Updated on 2025-08-06
54
Participants Needed
1
Research Sites
268 weeks
Total Duration
On this page
Sponsors
M
Medical University of South Carolina
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS). The objective of this study is to better understand the FOG response to DBS. Prior to DBS, participants will undergo an MRI scan, behavioral assessment related to walking, a cognitive evaluation, and assessment of other Parkinson's disease symptoms. Following DBS, participants will repeat these assessments at multiple timepoints over the period of one year. Overall, participants will complete a total of 7 visits over a period of approximately 1 year.
CONDITIONS
Official Title
Imaging Biomarkers of FOG Response to DBS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 40 years of age
- Diagnosed with Parkinson's Disease based on UK Brain Bank criteria
- Experience Freezing of Gait with a positive score on the nFOGQ and confirmed by evaluation
- Clinically selected to undergo subthalamic nucleus Deep Brain Stimulation surgery
You will not qualify if you...
- History of significant gait problems unrelated to Parkinson's Disease, such as orthopedic deformities
- Unable to complete timed-up-and-go walking tests in the OFF medication state without help or assistive devices
- Have contraindications to MRI, including inability to lie still, pregnancy, or incompatible metal implants
- Have implanted DBS devices not compatible with 3 Tesla MRI scanners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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