Actively Recruiting
Imaging Biomarkers to Stratify the Risk of Barotrauma in ARDS
Led by Università Vita-Salute San Raffaele · Updated on 2025-08-06
100
Participants Needed
2
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The high incidence of barotrauma in patients with COVID-19-related acute respiratory distress syndrome (ARDS) (16.1%, with a mortality rate \>60%) provides rationale for considering COVID-19 ARDS a paradigm for lung frailty. The investigators recently discovered that the Macklin effect is an impressive radiological predictor of barotrauma in COVID-19 ARDS. Since lung frailty is a major issue also in non-COVID-19 ARDS (6% barotrauma, with a mortality rate of 46% ) the investigators want to confirm the importance of Macklin effect in non-COVID-19 ARDS. Using artificial intelligence-based approaches the investigators also want to identify imaging biomarkers to non-invasively assess lung frailty in a mixed cohort of COVID-19/non-COVID-19 ARDS patients. Furthermore, the investigators want to prospectively validate these biomarkers in a cohort of ARDS patients. This will provide a therapeutic algorithm for ARDS patients at high-risk for barotrauma, identifying those most likely to benefit from hyper protective strategies.
CONDITIONS
Official Title
Imaging Biomarkers to Stratify the Risk of Barotrauma in ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical and radiological signs of ARDS, according to Berlin criteria, requiring ICU admission
- Obtain duly signed informed consent
You will not qualify if you...
- Poor quality imaging due to motion or respiratory artifacts
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Ospedale Mater Domini
Catanzaro, Calabria, Italy
Actively Recruiting
2
IRCCS San Raffaele Scientific Institute
Milan, MI, Italy, 20132
Actively Recruiting
Research Team
D
Diego Palumbo, MD
CONTACT
A
Alessandro Belletti, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here