Actively Recruiting
Imaging - Clinical Evaluation of Altered Nervous System Drainage
Led by IRCCS Eugenio Medea · Updated on 2024-05-29
100
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
I
IRCCS Eugenio Medea
Lead Sponsor
M
Ministry of Health, Italy
Collaborating Sponsor
AI-Summary
What this Trial Is About
The current study aims to evaluate the aspects of perfusion, fluid diffusivity in the interstitium and the T1 and T2 signal of the PVS and WMH. The current study has the following objectives: a) evaluate the perfusion aspects using the gadolinium-based contrast medium of brain tissues in the short term; b) the direction of flow of fluids at very low speed in the white matter using the DTI sequences configured for this purpose; c) T1-mapping of the lesions of interest. The expected results will help us understand two aspects of neurofluid dynamics: a) how the fluid moves within the central nervous system in the first minutes after the injection of the tracer (in our case the gadolinium-based contrast medium) and b) what is the composition of the fluid within the PVS and WMH and how can investigators characterize them more accurately.
CONDITIONS
Official Title
Imaging - Clinical Evaluation of Altered Nervous System Drainage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with white matter lesions and/or enlarged perivascular spaces
You will not qualify if you...
- Contraindications to the use of contrast medium
- Clinically unstable patients where prolonged sedation is inappropriate
- Presence of tumors
- Contraindications to perform MR
AI-Screening
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Trial Site Locations
Total: 1 location
1
Scientific Institute IRCCS E. Medea
Bosisio Parini, Lecco, Italy, 23842
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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