Actively Recruiting
Imaging CRF X NOP Interactions in CUD
Led by Rajesh Narendran · Updated on 2025-06-05
80
Participants Needed
1
Research Sites
400 weeks
Total Duration
On this page
Sponsors
R
Rajesh Narendran
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.
CONDITIONS
Official Title
Imaging CRF X NOP Interactions in CUD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males or females between 18 and 55 years old
- For CUD group: Fulfill DSM-5 criteria for cocaine use disorder
- For healthy controls: No present or past DSM-5 disorders except nicotine dependence
- No current abuse of opiates, sedative-hypnotics, amphetamines, MDMA, moderate to severe alcohol or cannabis use
- Not currently on prescription medical or psychotropic medications
- No current or past severe medical, endocrine, or neurological illnesses
- No metallic objects in the body contraindicated for MRI
- No significant radioactivity exposure in past year exceeding guidelines
- Not currently pregnant or breastfeeding
You will not qualify if you...
- Presence of other current DSM-5 psychiatric or addictive disorders besides cocaine use disorder
- Current abuse within six months of opiates, sedative-hypnotics, amphetamines, MDMA, moderate to severe alcohol or cannabis use
- Use of prescription medical or psychotropic medications
- Severe medical, endocrine, or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia
- Pregnancy or breastfeeding
- History of significant radioactivity exposure exceeding guidelines
- Presence of metallic objects contraindicated for MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
R
Rajesh Narendran, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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