Actively Recruiting
Imaging Depression in Parkinson's Disease
Led by Yale University · Updated on 2026-03-10
120
Participants Needed
1
Research Sites
273 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to identify targetable neural substrates of depression in Parkinson's Disease for the first time in people with Parkinson's between the ages of 40 and 80, who are experiencing symptoms of depression.
CONDITIONS
Official Title
Imaging Depression in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 to 80 years
- Negative pregnancy test for women of reproductive potential at screening and scanning
- Clinical diagnosis of Parkinson's Disease and ability to consent and tolerate PET procedures
- For Parkinson's patients with depression, at least moderate symptom severity (MADRS score of 15 or higher)
- For depressed Parkinson's patients receiving ketamine, abstinence from drugs of abuse except alcohol, cannabis, nicotine, and caffeine during the study; no substance use disorder as defined by DSM-5
You will not qualify if you...
- Dementia with Montreal Cognitive Assessment (MoCA) score less than 21
- Significant primary psychiatric disorder other than major depressive disorder
- Unstable or significant medical or neurological illness other than Parkinson's Disease that increases risk or affects study objectives
- Prior research radiation exposure exceeding FDA annual limits
- Use of medications affecting SV2A availability (e.g., levetiracetam)
- For ketamine patients, uncontrolled hypertension (blood pressure ≥140/90 mmHg)
- Contraindications to MRI
- For arterial sampling in PET scan: iodine allergy, bleeding disorder, or use of blood-thinning medication
- Inability to provide written informed consent according to Yale Human Investigation Committee guidelines in English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
Research Team
S
Sophie Holmes
CONTACT
L
Libby DiDomizio
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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