Actively Recruiting
Imaging Histone Deacetylase in the Heart
Led by Massachusetts General Hospital · Updated on 2025-12-22
96
Participants Needed
1
Research Sites
416 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.
CONDITIONS
Official Title
Imaging Histone Deacetylase in the Heart
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 18 to 85 years with no known medical diseases for the healthy volunteer group
- Adults aged 18 to 85 years with a diagnosis of diabetes and no signs of left ventricular hypertrophy or heart failure with preserved ejection fraction for the diabetes group
- Adults aged 18 to 85 years with documented left ventricular hypertrophy and degenerative calcific aortic stenosis for the aortic stenosis group
- Ability to provide informed consent
You will not qualify if you...
- Known contraindication to MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
D
David E Sosnovik, MD
CONTACT
A
Anne L Philip, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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