Actively Recruiting
Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)
Led by University of Rochester · Updated on 2025-03-20
40
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
U
University of Rochester
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Lymphatic transport was previously examined by these investigators using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) of the upper extremities. They established reliable and reproducible methodologies in RA patients. The purpose of this phase 2 pilot is to study RA disease progression and effectiveness as well as the mechanism of action of clinical interventions using established NIR-ICG methodologies in previous studies.
CONDITIONS
Official Title
Imaging of Lymphatic Vessels in People with Rheumatoid Arthritis (RA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide written informed consent
- Be 18 years old or older
- Fulfill 2010 American College of Rheumatology criteria for Rheumatoid Arthritis with a DAS28-C-Reactive Protein (CRP) score above 3.5
- Have early RA with disease duration of 1 year or less, or established RA with at least 10 years of disease
- For early RA: must be methotrexate inadequate responder (DAS28-CRP >2.6 at 4 months) or experiencing a flare on methotrexate and starting anti-TNF therapy
- For established RA: must be on a stable dose of DMARD, Janus Kinase inhibitor, or biologic agent for at least 8 weeks
- Have active synovitis in one or both hands confirmed by ultrasound
You will not qualify if you...
- Have active systemic disorders or inflammatory conditions other than RA, including chronic hepatitis B, hepatitis C, or HIV infections
- Have known sensitivity to iodine due to residual iodide in Indocyanine Green
- Are pregnant (pregnancy tests will not be performed)
- Have inability to donate blood due to poor venous access
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
J
Joseph Solomon, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here