Actively Recruiting
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Led by University of Texas Southwestern Medical Center · Updated on 2026-03-12
28
Participants Needed
1
Research Sites
22 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Investigators propose to develop hyperpolarized \[13C\]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesis of a neurotransmitter in this observational study.
CONDITIONS
Official Title
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 through 60 years of age
- Healthy with no neurological abnormalities
- Ability to understand and willing to sign written informed consent
- Able to read and speak English
- All races and ethnicities are eligible
You will not qualify if you...
- Metallic foreign bodies on the scalp or cranium interfering with MRI
- Major debilitating neurological diseases such as stroke, dementia, or tumor
- Under influence of illicit drugs altering brain metabolism at the time of scanning
- Under influence of antiepileptic drugs at the time of scanning
- Any contraindications to MRI including implants not allowed at 3T, pacemakers, ICD
- Claustrophobia
- Medically unstable conditions including heart failure, severe LVOT obstruction, unstable angina
- Pregnancy or lactation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UT Southwestern - Advanced Imaging Research Center
Dallas, Texas, United States, 75390
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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