Actively Recruiting
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
Led by University of Pennsylvania · Updated on 2025-10-03
100
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to measure the extent of lung inflammation between different groups of participants using a radioactive tracer called \[18F\]NOS. A radioactive tracer is a type of imaging drug that is labeled with a radioactive tag and injected into the body.
CONDITIONS
Official Title
Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be 18 to 45 years old
- Current e-cigarette use of nicotine at least 5 days per week for the past year with no cigarette smoking or cannabis use in the past 30 days
- Current e-cigarette use of cannabis at least 5 days per week for the past year with no cigarette smoking or nicotine use in the past 30 days
- Current cigarette smoking of at least 5 cigarettes per day, 4 days per week for the past year with no e-cigarette use in the past 30 days
- Current dual use of cigarettes and e-cigarettes (cannabis and/or nicotine) at least 5 days per week for the past year
- Non-smokers with less than 100 lifetime cigarettes, e-cigarette uses, and cannabis uses
- Willingness to provide informed consent and participate according to guidelines
You will not qualify if you...
- Females who are pregnant or breastfeeding at screening
- Current untreated or unstable substance use disorder except nicotine or cannabis use disorder
- Positive urine drug screen for opiates, methamphetamine, or cocaine at screening
- Current unstable or untreated major depression or psychotic disorder
- Use of inhaled or oral corticosteroids or anti-inflammatory medications
- History of lung trauma
- Active or recent (within 4 weeks) lung infection or lung disease affecting tracer uptake
- Inability to tolerate imaging procedures as determined by investigator
- Any medical condition that could compromise safety or study participation per physician assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
E
Erin Schubert
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
6
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