Actively Recruiting
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity in Survivors of Childhood Acute Lymphoblastic Leukemia
Led by St. Jude Children's Research Hospital · Updated on 2026-05-18
60
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying survivors of childhood Acute Lymphoblastic Leukemia (ALL) and healthy volunteers to understand the relationship between cancer, cancer treatment, and muscle weakness. The study focuses on muscle mitochondrial oxidative phosphorylation (mtOXPHOS) activity and satellite cell content, exploring their association with muscle strength, physical performance, muscle morphology, and epigenetics. This research aims to better understand how impaired cellular function in muscle cells may contribute to muscle weakness seen in ALL survivors. The study uses advanced non-invasive imaging techniques including magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to measure mtOXPHOS activity in the calf muscles of participants. Both ALL survivors and age- and sex-matched healthy controls will undergo two MRI sessions. Additional assessments include muscle ultrasound, physical function tests, and muscle biopsies. Blood samples will also be collected to study muscle morphology, mitochondrial health, and epigenetic differences. Participants will attend visits that include MRI scans, physical strength and function assessments, muscle ultrasound, and sample collections. Researchers will measure mtOXPHOS capacity using various imaging and biopsy methods and assess muscle strength and physical performance. The study will monitor differences between survivors and controls and evaluate the feasibility of these imaging techniques. Total participation duration varies, with multiple appointments required to complete all assessments and sample collections.
CONDITIONS
Brief Title
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Survivor or Control participant is 18 years old or older at time of consent and enrolled in SJLIFE.
- Survivor participant is a childhood ALL survivor.
- Survivor or Control participant has low muscle mass defined by a relative lean mass z-score of -0.5 or lower.
- Participant is able and willing to give informed consent.
You will not qualify if you...
- Survivor participant has history of cranial radiation.
- Participant has implanted medical devices or metal that interfere with MRI or MRS.
- Female participant is pregnant.
- Participant is taking anticoagulant medications such as aspirin, apixaban, coumadin, edoxaban, or rivaroxaban.
- Participant weighs more than 300 pounds.
- Participant is allergic to local anesthetics like lidocaine or bupivacaine.
- Participant cannot lie flat on their back for 90 minutes or longer.
- Participant has current peripheral motor neuropathy.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - 1 to 2 weeks
Participants undergo non-invasive imaging assessments including MRI, MRS, and muscle ultrasound to measure skeletal muscle mitochondrial function and muscle volume. Physical function assessments and biological samples such as peripheral blood and muscle biopsies are also collected to evaluate muscle morphology and mitochondrial health.
2 MRI/MRS appointments and 1 Human Performance Lab visit with physical assessments and muscle ultrasound; blood and muscle samples collected during these visits
Duration - Up to study completion
Participants are monitored to explore and describe differences in muscle mitochondrial function and morphology over time as related to their physical performance and muscle health.
No scheduled visits; ongoing data analysis and observation
Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
P
Puneet Bagga, PhD
P
Puneet Bagga, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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