Actively Recruiting
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
Led by St. Jude Children's Research Hospital · Updated on 2026-04-23
60
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow. Primary Objective • To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls. Secondary Objective * To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors. * To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.
CONDITIONS
Official Title
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is 18 years old or older and enrolled in SJLIFE
- Participant is a childhood ALL survivor or control
- Participant has low muscle mass defined by relative lean mass z-score ≤ -0.5 SD
- Participant is able and willing to give informed consent
You will not qualify if you...
- Survivor has a history of cranial radiation
- Participant has implanted medical devices or metal that interfere with MRI or MRS
- Female participant is pregnant
- Participant is taking anticoagulant medications
- Participant weighs more than 300 pounds
- Participant is allergic to local anesthetics like lidocaine or bupivacaine
- Participant cannot lie flat on their back for 90 minutes or longer
- Participant has current peripheral motor neuropathy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
Research Team
P
Puneet Bagga, PhD
CONTACT
P
Puneet Bagga, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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