Study of Muscle Mitochondrial Function and Physical Performance in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

What this Trial Is About

Researchers are studying survivors of childhood Acute Lymphoblastic Leukemia ALL and healthy volunteers to understand the relationship between cancer, cancer treatment, and muscle weakness. The study focuses on muscle mitochondrial oxidative phosphorylation mtOXPHOS activity and satellite cell content, exploring their association with muscle strength, physical performance, muscle morphology, and epigenetics. This research aims to better understand how impaired cellular function in muscle cells may contribute to muscle weakness seen in ALL survivors. The study uses advanced non-invasive imaging techniques including magnetic resonance imaging MRI and magnetic resonance spectroscopy MRS to measure mtOXPHOS activity in the calf muscles of participants. Both ALL survivors and age- and sex-matched healthy controls will undergo two MRI sessions. Additional assessments include muscle ultrasound, physical function tests, and muscle biopsies. Blood samples will also be collected to study muscle morphology, mitochondrial health, and epigenetic differences. Participants will attend visits that include MRI scans, physical strength and function assessments, muscle ultrasound, and sample collections. Researchers will measure mtOXPHOS capacity using various imaging and biopsy methods and assess muscle strength and physical performance. The study will monitor differences between survivors and controls and evaluate the feasibility of these imaging techniques. Total participation duration varies, with multiple appointments required to complete all assessments and sample collections.

Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors