Actively Recruiting

Phase 1
Age: 18Years +
All Genders
NCT04621435

Imaging of Solid Tumors Using FAP-2286

Led by Thomas Hope · Updated on 2025-12-31

191

Participants Needed

1

Research Sites

315 weeks

Total Duration

On this page

Sponsors

T

Thomas Hope

Lead Sponsor

S

Society of Abdominal Radiology

Collaborating Sponsor

AI-Summary

What this Trial Is About

This is a multi-arm prospective trial that evaluates the ability of a novel imaging radiolabeled agents to detect metastatic cancer in participants with solid tumors using a gallium 68 (68Ga-) or copper 64 (64Cu-) FAP-2286 tracer. FAP-2286 is a peptidomimetic molecule that that binds to Fibroblast Activation Protein (FAP). FAP is a transmembrane protein expressed on cancer-associated fibroblasts, and has been shown to be present on a number of solid tumors.

CONDITIONS

Official Title

Imaging of Solid Tumors Using FAP-2286

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Histopathologically confirmed solid tumors in specified cohorts
  • Cohort 1: Tumor type agnostic, measurable disease not required
  • Cohort 2: Metastatic disease present with measurable disease or multiple bone metastases, with specific cancer types including breast, pancreas, sarcoma, prostate, bladder, colon, or other confirmed cancers
  • Cohort 3: No evidence of metastatic disease, eligible for imaging at initial staging or after definitive therapy with high risk of recurrence, including head and neck or bladder cancer
  • Ability to understand and sign informed consent
Not Eligible

You will not qualify if you...

  • Unlikely to comply with study procedures or judged unsuitable by investigator
  • Known pregnancy

AI-Screening

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Trial Site Locations

Total: 1 location

1

University of California, San Francisco

San Francisco, California, United States, 94143

Actively Recruiting

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Research Team

M

Maya Aslam

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

4

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