Actively Recruiting
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
Led by University of Pittsburgh · Updated on 2025-06-13
100
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
Northwestern University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
CONDITIONS
Official Title
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Cohort 1 (neurotypical adults): Age 18 to 49 years
- Cohort 1: Right-handed
- Cohort 1: Native English speaker
- Cohort 2 (people with cerebellar lesions): Age 18 years or older
- Cohort 2: Right-handed
- Cohort 2: Native English speaker
- Cohort 2: History of cerebellar stroke
- Cohort 3 (controls matched to Cohort 2): Age 18 years or older
- Cohort 3: Right-handed
- Cohort 3: Native English speaker
You will not qualify if you...
- Presence of MRI risk factors such as metal or electromagnetic devices in the body, previous shrapnel injuries, use of intrauterine device containing metal, claustrophobia, or pregnancy
- History of neurological or neurodegenerative disease or severe brain injury (e.g., stroke, traumatic brain injury) except for cerebellar stroke in Cohort 2
- Hearing loss greater than 25 dB hearing level at octave frequencies 250-8000 Hz for Cohort 1
- Hearing loss greater than 50 dB hearing level at octave frequencies 250-4000 Hz for Cohorts 2 and 3
- Clinical diagnosis or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis or treatment for neurocognitive disorders such as dementia or delirium
- Presence of severe and unmanaged clinically diagnosed attention disorder
- Clinical diagnosis or treatment for speech, language, or hearing disorders (except for Cohort 2)
- Head circumference greater than 60 cm or weight greater than 300 pounds
- History of severe claustrophobia
- Currently pregnant or possibly pregnant
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15260
Actively Recruiting
Research Team
J
Jason W Bohland, Ph.D.
CONTACT
A
Alexander Ocampo, B.A.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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