Actively Recruiting
Immediate and Functional Results of Different Types of Reconstructions After Proximal Gastrectomy For Gastric and Esophagogastric Junction Cancer
Led by P. Herzen Moscow Oncology Research Institute · Updated on 2026-04-22
400
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
P
P. Herzen Moscow Oncology Research Institute
Lead Sponsor
A
A.Loginov Moscow Clinical Scientific Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Proximal gastric and esophagogastric junction cancers make up about 40% of all stomach cancers. This research focuses on patients with localized tumors who undergo proximal gastrectomy, a surgery removing the upper stomach and part of the esophagus. The study aims to compare different ways to reconstruct the digestive tract after surgery and understand how these affect patient quality of life, symptoms like reflux, food passage, and nutritional status, which are often overlooked in favor of cancer survival outcomes. The study observes patients who have had proximal gastrectomy using various reconstruction techniques such as direct esophagogastrostomy, double-tract reconstruction, jejunal interposition, and newer anti-reflux surgeries. It tracks patients treated by open, laparoscopic, or robotic surgery from January 2025 to December 2026. Patients are grouped based on whether they experience any complications after surgery to assess how reconstruction methods influence these outcomes. Participants will be monitored for up to one year after surgery with evaluations including complications within 90 days, survival, tumor progression, and local recurrence. Functional outcomes like reflux esophagitis, anastomotic stricture, dumping syndrome, body weight, hemoglobin levels, and food passage will be assessed at 6 and 12 months. This comprehensive follow-up aims to provide detailed information on the immediate and long-term effects of different reconstruction methods on patients' health and quality of life.
CONDITIONS
Brief Title
Immediate and Functional Results of Different Types of Reconstructions After Proximal Gastrectomy For Gastric and Esophagogastric Junction Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with primary gastric or esophagogastric junction cancer (including Siewert I and II)
- Clinical stage cT1-3N0-2M0 disease
- Scheduled for proximal gastrectomy with curative intent via open, laparoscopic, or robotic approach
- Surgery planned between January 1, 2025, and December 31, 2026
You will not qualify if you...
- Evidence of metastatic disease or positive peritoneal cytology from staging laparoscopy
- Presence of other synchronous cancers
- Esophagogastric Junction Siewert I malignancy
- Emergency surgery or surgery without curative intent
- Undergoing additional surgery beyond curative procedure for primary esophageal or esophagogastric junction cancer
- Previous surgery on stomach or colon
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Hospital stay around surgery
Participants undergo proximal gastrectomy with different types of digestive system reconstruction and receive immediate post-operative care.
1 surgery visit and hospital stay
Duration - Up to 1 year after surgery
Participants are monitored for postoperative complications, functional outcomes, and quality of life after surgery.
Visits at 6 months and 12 months after surgery
Trial Site Locations
Total: 1 location
1
P.Herzen Moscow Oncological Research Institute
Moscow, Russia
Actively Recruiting
Research Team
A
Andrey Ryabov, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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