Actively Recruiting
Immune Cell Response to Stimuli
Led by National Institute of Environmental Health Sciences (NIEHS) · Updated on 2026-03-24
750
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them. It will determine how the cells may, under certain circumstances, contribute to inflammation, and will measure substances in the blood plasma (the liquid, non-cellular part of the blood) that might stimulate white blood cells, in order to understand how the blood responds to possible disease-related conditions. Healthy normal volunteers 18 years of age and older who weigh at least 110 pounds may be eligible for this study. Participants give about 320 milliliters (mL) of blood (about 1 1/3 cups) or less at each donation. They donate no more than once every 8 weeks and no more than six times a year. On some occasions, less than 320 mL of blood may be drawn. The collected blood is separated into its components and specific cells are exposed to substances to examine their response.
CONDITIONS
Official Title
Immune Cell Response to Stimuli
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Normal, healthy adult donors as judged by screening questionnaire
- Nonpregnant
- Weighing at least 110 lbs
- 18-65 years of age
- HIV negative (proof required every 6 months)
- Hepatitis B surface antigen and hepatitis C serology negative (checked every 6 months)
You will not qualify if you...
- Feeling ill within the last 24 hours
- Alcohol consumption in the last 24 hours
- Visit to the dentist in the last 24 hours
- A doctor visit for illness or vaccination in the last 2 weeks
- Diarrhea in the last 2 weeks
- Recurrent fever (4 weeks)
- Pregnant or suspected pregnancy in the last 6 weeks
- Blood or plasma donation that will cause the participant to exceed 550ml of blood in the last 8 weeks
- Receiving a blood donation in the past 12 months
- Bleeding disorder
- Anemia
- Heart problems
- Insulin dependent diabetes
- Problems with blood donation
- Risk of or evidence of Creutzfeldt-Jacob Disease in the family
- HIV-positive status, Hepatitis B/C-positive status or other confirmed or suspected immunosuppressive or immunodeficient conditions
- Use of immunosuppressants or other immune-modifying drugs
- Use of selected medications within the preceding 5 days unless the PI or AI receiving the samples states otherwise (NSAIDS/aspirin/tylenol, antidepressants, antihistamines , corticosteroids, HMG CoA reductase inhibitors, and antihypertensives)
- Temperature over 99.5 F
- Blood pressure less than 90/50
- Blood pressure higher than 170/95 mm Hg
- Pulse rate less than 50 or greater than 100 beats/minute
- If blood donation exceeds 200ml: Hematocrit less than 34% for women or less than 36% for men, or greater than 56% for either gender. Patients will be informed of disqualifying vital signs and hematocrit values and advised by trained staff, as appropriate, to seek assistance from their physician.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
NIEHS Clinical Research Unit (CRU)
Research Triangle Park, North Carolina, United States, 27709
Actively Recruiting
Research Team
N
NIEHS Join A Study Recruitment Group
CONTACT
M
Michael B Fessler, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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