Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle.
Chad M Skiles, Zachary J Fennel, Paul-Emile Bourrant...
https://pubmed.ncbi.nlm.nih.gov/41891949Actively Recruiting
Phase Not Applicable
Age: 18Years - 85Years
All Genders
Healthy Volunteers
ID04416191
Muscle Immune Cells During Disuse and Recovery in Aging and Metabolic Disease
Led by University of Utah · Updated on 2025-12-05
45
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how muscle health recovers after a period of inactivity by studying healthy adults aged 18-35 and 60-85. This interventional study aims to understand muscle changes during and after a 2-week leg immobilization period. The study plans to enroll 45 participants and will take place over 1 to 2 months. Participants will undergo a series of visits including initial blood screening, oral glucose tolerance testing, muscle biopsies, blood draws, body composition scans, MRI, and muscle strength testing. After the second visit, participants will have their leg immobilized for 14 days at home using provided equipment. Additional visits include blood draw during immobilization and multiple assessments shortly after immobilization ends. Throughout the study, researchers will monitor thigh muscle volume and leg muscle strength before and after immobilization. Activity levels will be tracked with a step monitor, and dietary assessments will be conducted. The study involves multiple muscle biopsies and imaging tests to measure muscle health and recovery, with the total participation lasting up to two months.
CONDITIONS
Brief Title
Immune Cells During Disuse and Recovery
Who Can Participate
Age: 18Years - 85Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age between 18-35 or 60-85 years
- Ability to sign informed consent
- Living independently before study admission
You will not qualify if you...
- History of cardiovascular disease such as heart failure or coronary artery disease
- History of endocrine or metabolic diseases like thyroid problems or diabetes
- History of kidney disease or failure
- Presence of vascular disease or risk of deep vein thrombosis
- Use of anticoagulant medications
- Elevated blood pressure above 150/100 mmHg
- Implanted electronic devices like pacemakers
- Cancer diagnosed or treated within the last year, except basal cell carcinoma
- Currently following a weight-loss diet
- Recent or ongoing corticosteroid use for 2 weeks or more
- Use of androgens or growth hormone within 6 months
- History of stroke with motor disability
- Recent gastrointestinal bleeding within 12 months
- History of liver or respiratory diseases
- Pregnancy confirmed by test
- Employment as staff reporting directly or indirectly to the investigator
- Any other condition deemed exclusionary by the principal investigator or faculty physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Baseline Assessment
Duration - Up to 1 week
Participants undergo baseline testing including blood draws, oral glucose tolerance test, body composition scan, MRI, muscle strength testing, and dietary assessment. Participants also receive a step activity monitor to track their activity levels.
2 visits (in-person)
Limb Immobilization
Duration - 14 days
Participants undergo a 2-week period of leg immobilization using equipment and instructions provided.
1 visit during immobilization for blood draw
Post-immobilization Assessments
Duration - 7 days after immobilization
Participants return for multiple assessments including biopsies, blood draws, body composition scans, MRI, and muscle strength testing at the end of immobilization and during recovery.
3 visits (in-person)
Trial Site Locations
Total: 1 location
1
The University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
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Research Team
M
Micah Drummond, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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