Actively Recruiting
Immune Checkpoint Inhibitor Therapy for Cancer and Risk of Myocarditis or Cardiomyopathy
Led by Sunnybrook Health Sciences Centre · Updated on 2024-06-07
15
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients undergoing dual treatment with Immune checkpoint inhibitors (ICI) for various cancers, e.g. melanoma, are at increased risk of developing myocarditis and cardiomyopathy. Currently, only limited data on serial myocardial tissue changes during treatment and whether they predict outcomes are available. Cardiac MRI (CMR) is the reference standard for non-invasive myocardial volumes/function analysis and uniquely characterizes myocardial tissue. Therefore, it may help detect myocardial tissue changes during treatment and help early treatment and prevent adverse cardiac outcomes.
CONDITIONS
Official Title
Immune Checkpoint Inhibitor Therapy for Cancer and Risk of Myocarditis or Cardiomyopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older with skin cancer eligible for treatment with nivolumab, pembrolizumab, or ipilimumab
- Able to provide informed consent
- Able to travel to the study site for cardiac imaging
You will not qualify if you...
- Life expectancy of 12 months or less
- Currently participating in another clinical trial
- Previous treatment with immune checkpoint inhibitors
- History of cardiac disease such as heart failure, myocardial infarction, atrial fibrillation, or unstable angina
- Pregnant
- Impaired kidney function with GFR of 30 mL/min or less
- Contraindications to MRI such as having a pacemaker
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
Research Team
C
Christian Houbois, MD
CONTACT
N
Navpreet Sekhon, MB Bch BAO
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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