Actively Recruiting
Immune Dynamics in the Natural History of Chronic HBV Infection
Led by Nanfang Hospital, Southern Medical University · Updated on 2025-09-30
5000
Participants Needed
1
Research Sites
930 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this observational study is to follow up on chronic HBV-infected patients over a long period of time to understand the changes in the immune status as age increases and the natural history of chronic HBV infection progresses. The main questions it aims to answer are: * Does the natural history of chronic HBV infection progress with changes in HBV-specific immunity? * What is the role of age in the natural history of chronic HBV infection? Patients with chronic HBV infection who are untreated and aged 1-80 years will be followed up every six months. During each follow-up, HBV-related serological and virological indicators will be tested. Peripheral blood samples will also be collected to test HBV-specific immunity and the immune environment.
CONDITIONS
Official Title
Immune Dynamics in the Natural History of Chronic HBV Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 1 and 80 years, male or female
- Diagnosed with chronic hepatitis B virus infection according to 2019 guidelines
- No antiviral treatment (including nucleoside analogs and interferons) within the past six months
You will not qualify if you...
- Co-infection with hepatitis C virus (HCV) or HIV
- Alcoholic fatty liver disease, non-alcoholic fatty liver disease, or autoimmune liver diseases
- Immune system diseases such as hyperthyroidism
- Coagulation disorders including diabetes mellitus or idiopathic thrombocytopenic purpura
- Severe underlying diseases affecting immune status
- Other conditions deemed unsuitable for enrollment by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
Research Team
Y
Yongyin Li, Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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