Study of Immune System Balance in Adults With Sepsis and Septic Shock Using Blood Analysis Methods

What this Trial Is About

Researchers are studying the immune response and its changes in patients with sepsis and septic shock using advanced techniques like transcriptomics, flow cytometry, and cytokine analysis. This observational study aims to describe immune system behavior in these critical conditions and compare it with non-septic critically ill patients and healthy controls. The study involves three participant groups those with sepsis or septic shock, a demographically matched group of critically ill patients without sepsis, and healthy volunteers. Researchers will collect blood samples to analyze immune cells and cytokines using flow cytometry, transcriptomics, and ELISA methods. The main assessments will take place between 2024 and 2026, with additional diagnostic immune status panels conducted between 2026 and 2028. Participants will be monitored through blood analyses to evaluate immune system changes over time. The study tracks detailed immune responses to better understand sepsis and septic shock. The total participation duration extends with follow-up evaluations for immune status panels through 2028. This study is conducted by Charles University, Czech Republic, and includes adult participants aged 18 and older who provide consent within 24 hours of septic shock diagnosis.

Immune Homeostasis in Sepsis and Septic Shock