Actively Recruiting
Immune Infiltrate Analysis of Psoriasis Skin During Therapy With Anti-interleukin 23 (IL-23)
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-01-24
20
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Psoriasis is an immune-mediated inflammatory skin disease characterized by the presence of erythematous and itchy plaques. Psoriasis has a multifactorial pathogenesis, environmental and genetic factors contribute to its development. Although interleukin-23 blockade has been shown to be highly effective in the treatment of psoriasis, relapses have occurred during therapy. Our study aims to identify the cellular source of key cytokines involved in disease recurrence or persistence of at least one psoriatic lesion in patients affected by moderate- severe psoriasis treated with an anti-IL-23 biologic drug. The immune infiltrate of resistant or relapsed plaques during anti-IL-23 therapy will be analysed from skin biopsies.
CONDITIONS
Official Title
Immune Infiltrate Analysis of Psoriasis Skin During Therapy With Anti-interleukin 23 (IL-23)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Moderate to severe psoriasis with a PASI score greater than 10
- Receiving anti-IL-23 biologic therapy for at least 6 months (for patients under treatment)
- During therapy, having at least one area resistant to treatment or at least one disease flare (for patients under treatment)
- Ability to provide informed consent
You will not qualify if you...
- Unable to provide informed consent
- Complete response to anti-IL-23 therapy with no resistant plaques or disease flare-ups
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC Dermatologia
Rome, Lazio, Italy, 00168
Actively Recruiting
Research Team
K
Ketty Peris, Prof
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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