Actively Recruiting
Immune Profiles Evolution Under Immunotherapy for Melanoma
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-04-06
360
Participants Needed
1
Research Sites
518 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of the study aims to compare the immune profiles (circulating cytokines and lymphocytes) before and after (6 to 8 weeks) the first infusion of immune checkpoint inhibitors in patients with melanoma treated in the adjuvant setting(cohort A) or in metastatic setting(cohort B); and to study the association of these immune profiles with relapse- or progression-free survival.
CONDITIONS
Official Title
Immune Profiles Evolution Under Immunotherapy for Melanoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 65 18 years
- Totally resected stage III or IV melanoma treated with immune therapy (pembrolizumab, nivolumab, or other immune checkpoint inhibitors) as adjuvant treatment
- Unresectable stage IIIC/D or IV metastatic melanoma treated with immune therapy (pembrolizumab, nivolumab, or other immune checkpoint inhibitors) combined with radiotherapy
- Patient has been informed about the study and signed the consent
- Affiliated to the French social security scheme
You will not qualify if you...
- Pregnant or breastfeeding woman
- Patient refusal
- Patient receiving an immunosuppressor
- Undergoing general corticotherapy of > 10 mg/kg/day for more than 7 days
- Patient participating in another blinded interventional study receiving blinded treatment
- Patient without any social protection by organization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dermato-oncology department, Ambroise Paré hospital, APHP
Boulogne-Billancourt, France, 92100
Actively Recruiting
Research Team
E
Elisa FUNCK-BRENTANO, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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