Actively Recruiting
Immune Registry for BK in Kidney Transplant Recipients
Led by Virginia Commonwealth University · Updated on 2026-02-27
60
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
Sponsors
V
Virginia Commonwealth University
Lead Sponsor
E
Eurofins
Collaborating Sponsor
AI-Summary
What this Trial Is About
Kidney transplantation (KT) is the best treatment modality available to date for patients with advanced kidney disease and the success of KT is dependent on maintaining a selective intricate balance between the risk of rejection and infections in KT recipients. BK virus is an important clinical infection affecting the post-transplant outcomes in KT recipients. BK nephropathy can affect 8-15% of patients after KT causing acute kidney injury, increased risk of rejection and fibrosis leading to additional hospital stays, increasing overall health care cost burden, and in some cases graft loss. The exact pathogenesis and treatment options for BK nephropathy are not clearly understood. It is debatable whether BK nephropathy is a full fledge donor-derived infection or reactivation of the recipient's latent infection. Irrespective of etiology, the common consensus is that treatment of BK virus infection depends on the selective restoration of host immune responses and balancing the risk of rejection vs worsening of infection.
CONDITIONS
Official Title
Immune Registry for BK in Kidney Transplant Recipients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (over 18 years old) male and female kidney transplant recipients from deceased donors
- Only single organ transplants are included
- Participants must have recently been diagnosed with BK viremia
- Sub-study participants must have recently been diagnosed with BK viremia or have difficult-to-treat BK virus with a viral load not decreasing as expected
You will not qualify if you...
- Prisoners are not allowed to participate
- Multi-organ transplant recipients are excluded
- Pregnant women cannot participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
Research Team
A
Ambreen Azhar
CONTACT
G
Gelila Abebe
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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