Actively Recruiting
Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer
Led by Mayo Clinic · Updated on 2025-12-24
230
Participants Needed
1
Research Sites
416 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study gathers information from the blood cells and tumor tissue during treatment with anti-HER2 therapies, such as trastuzumab, pertuzumab, lapatinib, or neratinib, in patients with HER2 positive stage I-IV breast cancer who are scheduled to start anti-HER2 therapy. The information gained from this study may help researchers better understand the relation between cell response and anti-HER2 therapies.
CONDITIONS
Official Title
Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3E= 18 years
- Confirmed diagnosis of breast adenocarcinoma stage I-IV according to the American Joint Committee on Cancer staging 8th edition
- HER2 positive status as defined by current American Society of Clinical Oncology/College of American Pathologists guidelines
- Any estrogen receptor (ER) or progesterone receptor (PR) status
- Able and willing to provide written informed consent
- Willing to provide blood samples for research
- For Blood and Tissue Cohort: Scheduled to start new anti-HER2 therapy
- For Tissue-Only Cohort: Have received or completed anti-HER2 therapy
You will not qualify if you...
- Immunocompromised patients, including those known to have HIV
- Receiving systemic steroid or other immunosuppressive therapy within 30 days before registration (except inhaled steroids, low-dose corticosteroids equivalent to prednisone 10 mg daily or less, and steroids for nausea prevention)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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