Study of Immune Responses in Hospitalized Patients with Dengue and Sepsis Compared to Healthy Controls in Cambodia

What this Trial Is About

Researchers are investigating immune responses in people with serious dengue disease, sepsis, and healthy individuals to better understand how these conditions affect the bodys defenses. This observational study will enroll 200 hospitalized patients with dengue-like illness, 30 with sepsis, and 10 healthy controls to compare immune system activity, focusing on plasma leak syndromes and specific immune cells over time. Participants with dengue or sepsis will have blood samples collected at enrollment, day 1, and day 3, with dengue patients also having a sample taken at day 21. Healthy participants will provide one blood sample at enrollment. These samples will be analyzed for immune changes such as neutrophil behavior, cytokine levels, and adaptive immune responses as the diseases progress or improve. During the study, participants will provide clinical information and blood samples according to their group. Researchers will measure immune cell activity, gene expression, and serum markers to track disease progression and differences between dengue and sepsis. The study aims to identify key immune changes that could inform future treatments. Participation involves hospital visits up to 21 days with repeated blood draws, and the study will continue until December 2026.

Immune Responses to Dengue and Sepsis