Study of Immune System Patterns and Disease Control in Adults With Chronic Airway Inflammatory Diseases

What this Trial Is About

Researchers are studying how the immune system affects disease control in people with various chronic airway inflammatory diseases, including asthma, COPD, bronchiectasis, OSAS, and ABPA. The goal is to find links between immune cell patterns in the blood and disease severity or control. This observational study will compare immune features in patients and healthy volunteers to better understand immune differences and disease subtypes. Participants will provide blood samples for advanced immune cell analysis using CyTOF technology, cytokine profiling, and single-cell RNA sequencing. They will also undergo sputum testing to study microbial colonization and inflammatory cells. The study uses detailed immune and clinical data to identify markers linked to disease severity, control, and subtypes, aiming to guide future personalized immune therapies. During the study, participants will answer health and symptom questions, give blood samples, have lung function tests, and share sleep study results. Researchers will measure immune cell profiles, serum cytokines, sleep disorder severity, lung function, and quality of life scores. The study includes healthy volunteers for comparison and tracks many clinical and immune outcomes to understand disease control comprehensively.

Immune Status and Disease Control of Inflammatory Airway Diseases