Actively Recruiting
Association Between Immune Status and Disease Control in Patients With Inflammatory Airway Diseases
Led by First Affiliated Hospital of Ningbo University · Updated on 2026-03-25
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how the immune system affects disease control in people with various chronic airway inflammatory diseases, including asthma, COPD, bronchiectasis, OSAS, and ABPA. The goal is to find links between immune cell patterns in the blood and disease severity or control. This observational study will compare immune features in patients and healthy volunteers to better understand immune differences and disease subtypes. Participants will provide blood samples for advanced immune cell analysis using CyTOF technology, cytokine profiling, and single-cell RNA sequencing. They will also undergo sputum testing to study microbial colonization and inflammatory cells. The study uses detailed immune and clinical data to identify markers linked to disease severity, control, and subtypes, aiming to guide future personalized immune therapies. During the study, participants will answer health and symptom questions, give blood samples, have lung function tests, and share sleep study results. Researchers will measure immune cell profiles, serum cytokines, sleep disorder severity, lung function, and quality of life scores. The study includes healthy volunteers for comparison and tracks many clinical and immune outcomes to understand disease control comprehensively.
CONDITIONS
Brief Title
Immune Status and Disease Control of Inflammatory Airway Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older (40 years or older for COPD patients)
- Clinical diagnosis of asthma, ABPA, bronchiectasis, OSAS, or COPD based on established criteria
- PRISm patients with specific lung function criteria
- Smoking controls with at least 10 pack-years, normal lung function, no chronic respiratory symptoms
- Healthy controls with normal lung function, FeNO under 20 ppb, total IgE under 100 IU/mL, no chronic disease, smoking under 10 pack-years, and no immunosuppressant use within 3 months
You will not qualify if you...
- Severe respiratory diseases not included in the study like pulmonary embolism, pneumothorax, pulmonary hypertension, interstitial lung disease, or active lung cancer
- Severe systemic diseases interfering with study completion such as myocardial infarction, severe arrhythmia, liver or kidney failure, blood disorders, or malignancy
- Acute exacerbation within 4 weeks before enrollment or recent use of antibiotics, antifungals, immunosuppressive, cytotoxic, or corticosteroid drugs (except long-term maintenance therapy)
- Pregnant or lactating women
- Poor compliance as judged by investigators
- Current participation in other clinical studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline assessments
Participants undergo clinical diagnostic assessments, functional testing, and clinical scoring to classify their disease type and severity.
1 visit (in-person)
Duration - Baseline assessments
Blood and sputum samples are collected for deep immune profiling including CyTOF mass cytometry, cytokine ELISA, single-cell RNA sequencing, and microbiome analysis to characterize immune status and airway inflammation.
1 visit (in-person)
Duration - Up to study completion
Participants are observed over time to study the correlation between immune profiles and disease control, severity, and progression.
Periodic visits as needed
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, China
Actively Recruiting
Research Team
C
chao Cao, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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