Actively Recruiting
Immune-supportive Diet and Gut Permeability in Allergic Children
Led by Onze Lieve Vrouwe Gasthuis · Updated on 2025-05-01
132
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
Sponsors
O
Onze Lieve Vrouwe Gasthuis
Lead Sponsor
E
Ekhaga foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Peanut and nut allergy can be life threatening. Some patients have very low threshold levels (i.e. the amounts of peanut and nuts to which the patients react), others react to higher doses. The reasons for these differences in threshold are not well understood. Patients with peanut and nut allergy often suffer from other allergic diseases (atopic dermatitis, hay fever and asthma). A disturbed gut microbiota composition and an increased gut permeability may explain the development of allergic disease. We hypothesize that increased gut permeability is related to low threshold levels to peanuts or nuts. In addition, as it is known that nutrition can influence our gut permeability, we also hypothesize that a healthful immune-supportive diet restores gut permeability and alleviates symptoms. Therefore, the purpose of the study is to study in peanut and nut allergic children: 1. the relationship between gut permeability and threshold levels to peanut or nuts; 2. the effect of an immune-supportive diet on gut permeability, gut microbiome composition, coexisting allergic symptoms and quality of life
CONDITIONS
Official Title
Immune-supportive Diet and Gut Permeability in Allergic Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 3 to 17 years with a positive peanut or nut allergy challenge within 12 months or a clear IgE-mediated allergic reaction within 1 hour confirmed by sensitization within 24 months
- Children who are potty trained or house trained
- Presence of IgE to peanut ≥0.35 kU/l or positive skin prick test >3 mm to peanut or nut within 12 months prior to challenge
You will not qualify if you...
- Only mild oral symptoms to peanut or nut due to pollen food syndrome
- Negative peanut or nut challenge
- Children who are not potty trained or house trained
- Gastrointestinal diseases such as Crohn's disease, celiac disease, or ulcerative colitis, and lactose intolerance
- Severe cow's milk allergy
- Syndromes, infectious or immunological diseases other than atopy, or diabetes
- Use of laxative treatment such as lactulose
- Unable to read or write Dutch
AI-Screening
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Trial Site Locations
Total: 1 location
1
OLVG
Amsterdam, Netherlands
Actively Recruiting
Research Team
B
Berber Vlieg-Boerstra
CONTACT
C
Chantal den Elzen, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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