Effect of an Immune-supportive Diet on Gut Permeability and Allergic Symptoms in Children With Peanut and/or Nut Allergy

What this Trial Is About

Researchers are studying peanut and nut allergy in children aged 3 to 17 years to understand why there are differences in how sensitive children are to peanuts and nuts. The study focuses on the relationship between gut permeability, which is how easily substances pass through the gut lining, and the threshold levels that trigger allergic reactions. It also examines how an immune-supportive diet might improve gut health, reduce allergic symptoms, and enhance quality of life in these children. Peanut and nut allergies often occur alongside other allergic conditions like asthma and eczema, which are linked to inflammation and immune responses. The study compares two groups of children: one group follows an immune-supportive diet for 4 months alongside a peanut and nut-free diet, while the other group follows only the peanut and nut-free diet. The immune-supportive diet categorizes foods into three groups based on their effects on immune health, recommending some foods in ample amounts, others in limited amounts, and advising against certain foods. Researchers will monitor adherence to the diet through food diaries and self-assessments during and after the intervention. Participants will undergo various assessments including tests for small intestine permeability using urine samples, evaluations of allergic symptoms such as atopic dermatitis and asthma, and measurements of gut microbiota composition. These evaluations occur at the start and after 4 months of dietary intervention. Researchers will also assess quality of life, medication use, respiratory infections, and dietary adherence throughout the study. The primary outcome is the change in gut permeability after the dietary intervention, helping to clarify how diet may impact allergic responses in children with peanut and nut allergies.

Immune-supportive Diet and Gut Permeability in Allergic Children