Actively Recruiting
Immunoadsorption in Autoimmune Long COVID
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-01-05
70
Participants Needed
1
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Some people continue to have serious symptoms long after COVID-19, such as extreme fatigue and feeling worse after activity. In some patients, this may happen because the immune system is attacking the body by mistake. This study will test a treatment called immunoadsorption, which filters the blood to remove harmful antibodies. People with long COVID who have these antibodies will be randomly assigned to receive either the real treatment or a placebo. The main goal is to see whether fatigue improves after one month, and whether other symptoms and daily functioning improve over six months. This research will help us find out if this treatment can benefit the group of long COVID patients with immune-related disease.
CONDITIONS
Official Title
Immunoadsorption in Autoimmune Long COVID
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Long COVID based on the WHO-criteria
- Post-exertional malaise (PEM) according to the DSQ-PEM
- BELL's functionality score between 20% and 70%
- Good health before the long COVID diagnosis (WHO performance score 0)
You will not qualify if you...
- History of significant respiratory or cardiovascular disease
- Cardiac interventional procedure within 3 months before randomization
- Current immunosuppressive treatment for systemic autoimmune disorders
- Type 1 diabetes
- Solid organ cancer in the past 5 years
- Active psychiatric disorder under psychiatric treatment
- Body mass index over 35
- Fatigue existing before long COVID
- Poor performance score before long COVID diagnosis (WHO performance score above 0)
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
AUMC
Amsterdam, Netherlands
Actively Recruiting
Research Team
D
Daphne Schouten, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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