Actively Recruiting
Immunoadsorption Therapy in Managing NMDAR Antibodies Encephalitis
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2023-07-13
20
Participants Needed
1
Research Sites
257 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to assess the efficacy of immunoadsorption therapy (IA) on improving the neurological status of severe pediatric anti-NMDAR encephalitis patients.
CONDITIONS
Official Title
Immunoadsorption Therapy in Managing NMDAR Antibodies Encephalitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 0 to 18 years inclusive
- Diagnosis of autoimmune encephalitis with positive anti-NMDAR antibodies in cerebrospinal fluid
- PCPCS and mRS scores of 4 or higher after first-line therapy (steroids and/or intravenous immunoglobulins) when rituximab treatment is needed
- Signed informed consent from parents or legal guardians
- Affiliation with social insurance
You will not qualify if you...
- Autoimmune encephalitis without NMDAR antibodies
- PCPCS and mRS scores under 4 after first-line therapy
- Contraindications to central vascular access
- Pregnancy, breastfeeding, or lack of effective contraception in pubertal patients
- Contraindications to immunoadsorption therapy, including:
- Clinical conditions prohibiting temporary volume changes
- Conditions preventing anticoagulation with Heparin or ACD-A
- History of hypercoagulability
- Severe viral, bacterial, or fungal infections
- Severe immune deficiencies such as AIDS
- Suspected allergies to sheep antibodies or agarose
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Necker Enfants-Malades
Paris, France, 75015
Actively Recruiting
Research Team
I
Isabelle DESGUERRE, MD, PhD
CONTACT
A
Aminata TRAORE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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