Actively Recruiting
Immunoadsorption for Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Led by University of Ulm · Updated on 2025-09-11
140
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
U
University of Ulm
Lead Sponsor
F
Fresenius Medical Care Deutschland GmbH
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is designed as an explorative study aiming at exploring safety and efficacy of immunoadsorption (IA) in patients with Chronic Inflammatory Demyelinating Poly-neuropathy (CIDP) compared to intravenous immunoglobulins (IVIg) and methyl-prednisolone (MP). For this purpose, approximately 140 patients with CIDP will be included within the framework of the German multicenter network "Kompetenznetz Peripherer Nerv" (KKPNS). The study will be purely observational. IA will be performed as an escalation therapy, i.e., in patients who did not respond to IVIg and/or MP treatment. Patients will be included in the study during ongoing IVIg or MP treatment and switched to IA during the 18-month observation period in case of an insufficient response. IA will be performed according to the therapeutic scheme of each participating center. A non-mandatory recommendation for number of sessions, treatment volumes, and frequency will be given (see below). Six-month follow-up visits including collection of standardized clini-cal data will be performed.
CONDITIONS
Official Title
Immunoadsorption for Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of CIDP based on the EAN/PNS Guidelines on Diagnosis and Treatment of CIDP
- Age 18 years or older
- Willing and capable of giving written informed consent
- Currently receiving IVIg or MP treatment OR starting IVIg or MP treatment at baseline
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Ulm
Ulm, Baden-Wurttemberg, Germany, 89081
Actively Recruiting
Research Team
J
Johannes Dorst, Prof. Dr.
CONTACT
Z
Zeynep Elmas
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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