Actively Recruiting
Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2026-01-29
1250
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
S
Stand Up To Cancer
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research is being done to collect and store biological specimens (biospecimens) from people with cancer, regardless of tumor type, who are receiving treatments known or thought to have an effect on the immune system. The goal of this discovery and exploratory study is to: * Understand changes in the immune system associated with various cancer treatments, in order to better design new therapies or tests to predict how these treatments might work. * Identify risk factors for those who go on to develop side effects from immunotherapy. * Identify the molecular features associated with response and resistance to cancer therapies and immunotherapy using integrative genomic and immune repertoire characterization. * Capture and characterize systemic tumor burden by minimally invasive analyses of circulating tumor DNA. Participants may be asked to: * Donate samples of tumor, blood, lymph nodes, white blood cells, mouth cells (buccal smears) scraped from the inside of participant's cheek, urine, saliva, or other tissue samples. * Complete questionnaires about immunotherapy side effects at baseline and with follow-up appointments. * Undergo knee x-rays. * Allow the use of demographic and clinical information.
CONDITIONS
Official Title
Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a confirmed or suspected upper aerodigestive cancer and may receive immunomodulating treatments
- Able to understand and willing to sign the informed consent form
You will not qualify if you...
- Have significant problems making blood draw unsafe (e.g., hemoglobin less than 8.5 g/dL)
- Have significant issues making biopsy unsafe (e.g., severe bleeding disorders)
- Have significant risks making bronchoscopy unsafe (e.g., airway or serious heart problems)
- Unable or unwilling to read English and complete forms
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
V
Valsamo Anagnostou, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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