Actively Recruiting
Immunogenomic Dynamics and Biomarkers in Patients With Hepatocellular Carcinoma Receiving Immunotherapy
Led by Asan Medical Center · Updated on 2025-09-22
50
Participants Needed
1
Research Sites
326 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
1. Research purpose To perform genomic and immune profiling analysis on blood and tissue samples obtained from blood sampling and tumor biopsy in patients with advanced hepatocellular carcinoma with immuno-oncology treatment. 2. Research Subject Patients who will receive immuno-oncology treatment in recurrent, metastatic, and advanced liver cancer, who meet the selection criteria of the study, do not have exclusion criteria, and voluntarily agree to participate in the study. 3. Number of study subjects 50 people 4. Research Method 1) In patients with advanced hepatocellular carcinoma, peripheral blood will be collected at baseline before treatment, 6 weeks, 12 weeks, 24 weeks, 48 weeks after treatment, and at the time of cancer progression. 2\) Fresh tumors will be stored in the tissue obtained during the biopsy to perform genetic analysis
CONDITIONS
Official Title
Immunogenomic Dynamics and Biomarkers in Patients With Hepatocellular Carcinoma Receiving Immunotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with histologically confirmed hepatocellular carcinoma (HCC)
- Patients with locally advanced, recurrent, or metastatic HCC not eligible for surgery, liver transplantation, or radiofrequency ablation
- Patients who will receive immuno-oncology treatment
You will not qualify if you...
- Patients with fibrolamellar type HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
- Patients with other active cancers
- Patients eligible for local curative treatments such as surgery, liver transplantation, or radiofrequency ablation
- Patients who may cause confusion in clinical research results
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Asan Medical Center
Seoul, Song-pa, South Korea, 05505
Actively Recruiting
Research Team
J
Ju Hyun Shim
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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