Actively Recruiting
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
Led by MaineHealth · Updated on 2025-07-18
400
Participants Needed
1
Research Sites
626 weeks
Total Duration
On this page
Sponsors
M
MaineHealth
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.
CONDITIONS
Official Title
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Admitted to the intensive care unit after cardiac arrest episode
- Unresponsive after resuscitation
You will not qualify if you...
- Moribund or actively dying at the time of evaluation
- Informed consent cannot be obtained within 24 hours of resuscitation
- Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Maine Medical Center
Portland, Maine, United States, 04102
Actively Recruiting
Research Team
D
David B Seder, MD
CONTACT
S
Sergey Ryzhov, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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