Actively Recruiting
Immunoinflammatory State Detection and Multimodal Brain Imaging and Electrophysiologic Changes in Schizophrenia
Led by Central South University · Updated on 2025-04-24
200
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Schizophrenia is a severe mental illness that seriously affects the health and functioning of patients. Previous studies have found immunoinflammatory abnormalities in the blood, cerebrospinal fluid, central nervous system, and neuroimaging of people with schizophrenia, along with therapeutic effects of anti-inflammatory drugs on schizophrenia. These evidences suggest a close relationship between schizophrenia and immunity and inflammation. Therefore, we consider that the state of immune inflammation is a potential subtype classification basis for schizophrenia, and hypothesize that immune classification based on peripheral-central multidimensional data is related to patient's response to medication and cognition.
CONDITIONS
Official Title
Immunoinflammatory State Detection and Multimodal Brain Imaging and Electrophysiologic Changes in Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis that meets ICD-11 criteria for schizophrenia.
- Diagnosis of schizophrenia confirmed using the SCID-5-RV.
You will not qualify if you...
- Diagnosis or assessment confirming neurodevelopmental disorders, bipolar and related disorders, or substance use disorders (excluding alcohol and tobacco).
- Presence of severe or acute physical illnesses such as traumatic brain injury, intracranial infections or tumors, acute cardiovascular or respiratory diseases, acute blood disorders, or autoimmune diseases.
- Presence of defined genetic diseases including tuberous sclerosis, multiple sclerosis, Kleefstra syndrome, 22q11.2 deletion syndrome, Prader-Willi syndrome, or Klinefelter syndrome (47, XXY).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Psychiatry, the Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Actively Recruiting
Research Team
R
Renrong Wu, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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