Study of Immune and Clinical Factors in Advanced Peri-Implantitis Affecting Adults with Dental Implants

What this Trial Is About

Researchers are evaluating the causes and immune responses involved in advanced peri-implantitis, a condition affecting dental implants. This international study involves 100 adult volunteers from five European universities and explores two main theories about peri-implantitis development bacterial invasion around implants and an immune reaction triggered by titanium and other metals in the implant. The project also examines how the implant surface changes over time and its effects on surrounding tissues. Each participant will undergo clinical and radiological evaluations, including dental exams, Cone Beam Computed Tomography CBCT scans to measure bone loss and density, and blood tests to analyze inflammation and immune markers. Participants will have their affected implant surgically removed, with tissue samples collected for detailed laboratory analysis of titanium concentration, corrosion, and microscopic surface changes. Follow-up visits are scheduled one week and four weeks after surgery to assess healing, repeat blood tests, and perform additional CBCT scans. During the study, participants will receive medical interviews, oral hygiene and periodontal assessments, and blood sample collections before implant removal and four weeks later. Researchers will measure various blood markers, including inflammatory cytokines, lipid profiles, and vitamin D levels. Implant surfaces will be examined using microscopy and corrosion testing. The study monitors clinical outcomes and biological responses related to peri-implantitis to better understand its development and progression over time.

Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis