Actively Recruiting
Immunological Phenotype of Desmoid-fibromatosis-affected Patients.
Led by Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Updated on 2026-03-27
200
Participants Needed
8
Research Sites
79 weeks
Total Duration
On this page
Sponsors
F
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Lead Sponsor
C
Campus Biomedico - Roma
Collaborating Sponsor
AI-Summary
What this Trial Is About
This observational study aims to characterize the molecular, phenotypic, and functional inflammatory and immunological profile of patients with sporadic desmoid-type fibromatosis undergoing either active surveillance or systemic therapy. The study includes analysis of the tumor immune microenvironment (TIME), circulating immune and inflammatory molecules, immune cell subsets, and circulating tumor DNA (ctDNA). The goal is to identify biomarkers associated with spontaneous or treatment-induced tumor regression and to evaluate potential correlations with specific ß-catenin mutations.
CONDITIONS
Official Title
Immunological Phenotype of Desmoid-fibromatosis-affected Patients.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with primary sporadic desmoid-type fibromatosis with measurable disease under active surveillance
- Patients with primary sporadic desmoid-type fibromatosis with measurable disease receiving systemic treatment
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
IRCCS Istituto di Candiolo Fondazione del Piemonte per l'Oncologia
Candiolo, Italy
Not Yet Recruiting
2
Azienda Ospedaliero Universitaria Careggi
Florence, Italy
Not Yet Recruiting
3
Azienda Usl Toscana centro
Florence, Italy
Not Yet Recruiting
4
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy, 20133
Actively Recruiting
5
IRCCS Istituto Oncologico Veneto IOV
Padova, Italy
Not Yet Recruiting
6
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone"
Palermo, Italy
Not Yet Recruiting
7
Università Campus Bio-Medico
Rome, Italy
Not Yet Recruiting
8
Erasmus University Medical Centre
Rotterdam, Netherlands
Not Yet Recruiting
Research Team
C
Chiara Colombo, MD, Surgical Oncologist
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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