Actively Recruiting
Immunomodulation During Pregnancy
Led by Unidade Local de Saúde de Coimbra, EPE · Updated on 2025-03-19
30
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the effects of low dose aspirin in immunity Pregnant women taking aspirin for other reasons (preeclampsia prevention) will be studied. The main question it aims to answer is: evaluate the effect of LDA on the modulation of innate immunity cells (NK cells, monocytes, γδ T cells) and/or acquired immunity (B and T lymphocytes, Treg cells, Th cells). Participants already taking intervention A as part of their regular medical care for RA will answer online survey questions about their joint pain for 5 years.
CONDITIONS
Official Title
Immunomodulation During Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Singleton pregnancy
- Patients attending prenatal consultations at the Obstetrics Service A of CHUC, with the first consultation occurring before 14 weeks of gestation
- Gestational age determined by first-trimester ultrasound
- Study group: Women classified as high risk for PE according to clinical/historical criteria and the Fetal Medicine Foundation algorithm
- LDA-nafve (have not taken low-dose aspirin before)
You will not qualify if you...
- Multiple pregnancy
- Autoimmune diseases
- Prior use of low-dose aspirin or other immunomodulatory medication before potential recruitment
- History of spontaneous miscarriages and/or medical termination of pregnancy
- Fetal malformation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Unidade Local de Saúde de Coimbra, E.P.E.
Coimbra, Coimbra District, Portugal, 3000-075
Actively Recruiting
Research Team
A
Ana L Areia, PhD, MD
CONTACT
J
João Sargento-Freitas, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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