Actively Recruiting
Immunomonitoring of Mold Invasive Infections
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-11-20
20
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
U
URC-CIC Paris Descartes Necker Cochin
Collaborating Sponsor
AI-Summary
What this Trial Is About
Mold invasive infections are associated with an important mortality despite optimization of the antifungal treatment. In a few case reports, immune checkpoints inhibitors, initially developed for neoplastic diseases, have shown a potential beneficial effect in such devastating infections by restoring an efficient immune response. The investigators propose a longitudinal monitoring of the adaptative immune response, notably immune checkpoint expression on T cells, during mold invasive infections to help identify the patients who could benefit from the adjunction of immunotherapy and the optimal timing of such strategy.
CONDITIONS
Official Title
Immunomonitoring of Mold Invasive Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Mold invasive fungal infection: Aspergillus, Mucorales, Fusarium, or Scedosporium
- Infection proven or probable by 2019 EORTC/MGS criteria with modifications including diabetes and Mucorales PCR
- Within 14 days of invasive fungal disease diagnosis or have refractory infection defined by 2009 MGS/EORT failure criteria
- For aspergillosis or mucormycosis patients with ELISPOTs, total lymphocyte count above 700/mm3 on last sample
- No opposition to participate in the research
- Affiliated with or beneficiary of a social security system
You will not qualify if you...
- Bacterial co-infection in the last 14 days
- Previous treatment with anti-PD1 antibodies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Necker Enfants Malades
Paris, France, 75015
Actively Recruiting
Research Team
A
Alexandra SERRIS, MD, PhD
CONTACT
G
Gael PLASTOW, Project advisor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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