Actively Recruiting
Immunophenotyping of Blood Cells in the Diagnosis Work-up of Myelodysplastic Syndromes
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2024-07-10
300
Participants Needed
3
Research Sites
337 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by cytopenia(s), dysplasia in one or more major myeloid cell lines and progression to acute leukemia. Morphological analysis of peripheral blood (PB) and bone marrow (BM) remains the cornerstone of the diagnosis. Preliminary studies identified Flow Cytometry (FC) markers on red cells, platelets and circulating leukocytes that are expressed differently in MDS and in controls. However, these markers have been evaluated separately. The investigators propose to test in a large cohort of patients these markers, and to combine the most relevant ones in order to define a PB FC-based diagnosis score that would discriminate between MDS and non-clonal hematopoiesis and would avoid useless bone marrow samples in elderly
CONDITIONS
Official Title
Immunophenotyping of Blood Cells in the Diagnosis Work-up of Myelodysplastic Syndromes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient has been orally informed and given a short written information notice about the study
- Adult patient older than 18 years
- Blood sample analysis is routinely prescribed
- Presence of cytopenia in at least one blood cell lineage according to 2016 WHO criteria (Hemoglobin <100 g/L and/or platelets <150 G/L and/or neutrophils <1 G/L)
- Bone marrow analysis for morphology and cytogenetics must be planned due to suspicion of MDS
You will not qualify if you...
- Transfused patients who received red blood cell or platelet units less than 3 months ago
AI-Screening
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Trial Site Locations
Total: 3 locations
1
CHU Amiens-Picardie
Amiens, France, 80054
Actively Recruiting
2
CHRU Lille
Lille, France, 59000
Not Yet Recruiting
3
CHU Rouen
Rouen, France, 76031
Not Yet Recruiting
Research Team
L
Loïc Garçon, PD
CONTACT
A
Annabelle Boussault
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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