Study of Immune and Inflammatory Factors Affecting Outcomes in Patients Admitted to Intensive Care Units

What this Trial Is About

Researchers are conducting a prospective observational study to understand the immune and inflammatory factors that influence the outcomes of patients admitted to intensive care units ICU. The goal is to develop models that predict one-year survival and the risk of hospital-acquired infections in these critically ill patients. This study focuses on adults admitted to ICUs for various critical conditions including sepsis, brain injury, major surgery, and polytrauma. Patients in the ICU will have routine biological samples collected as part of their care, with additional minimal blood samples taken specifically for this study to analyze immune and inflammatory markers. Sampling will occur at admission, day 1, day 4, day 8, ICU discharge or day 28, and again at 12 months. Extra samples may be collected if significant clinical events like infections or complications occur during the ICU stay. Participants will be monitored through blood tests and flow cytometry to profile immune cells and inflammatory status over time. Researchers will also assess survival at 12 months and changes in organ failure scores during the first week. Molecular analyses such as transcriptomic profiling of immune cells will help understand changes from baseline to one year. The study involves no treatment intervention and will follow patients for a full year to gather comprehensive data on their immune response and outcomes after critical illness.

IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients