Actively Recruiting
Immunotolerance in Endometrial Cancer and at the Maternal-fetal Interface: Immunological Profiling of the Tumor Microenvironment in Risk Stratification of Recurrence
Led by Regina Elena Cancer Institute · Updated on 2024-05-31
30
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
R
Regina Elena Cancer Institute
Lead Sponsor
F
Federico II University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This pilot/exploratory study will be configured as a non-retro-prospective study interventional on endometrial tissue samples taken from surgically treated patients at the Regina Elena National Cancer Institute, IRE - IFO and stored at the Biobank of same Institute (BBIRE) (cohort 1) and on samples of decidualized endometrium and trophoblast from patients with ongoing spontaneous abortion treated surgically at the UOC of Gynecology ed Obstetrics of the Federico II University Polyclinic of Naples (cohort 2)
CONDITIONS
Official Title
Immunotolerance in Endometrial Cancer and at the Maternal-fetal Interface: Immunological Profiling of the Tumor Microenvironment in Risk Stratification of Recurrence
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 years
- Histological diagnosis of endometrial hyperplasia with or without atypia, endometrial carcinoma endometrioid histotype at any stage (FIGO I-IV), or patients undergoing hysterectomy for benign extra-endometrial disease
- Patients with recurrence or metastasis from endometrioid endometrial carcinoma undergoing surgery
- Adequate biological material available for planned analyses
- Written informed consent for prospective patients or those in follow-up
- Availability of stored samples and follow-up data for retrospective patients (at least 36 months)
- Diagnosis of ongoing spontaneous abortion undergoing uterine cavity review under hysteroscopic guidance
- Adequate biological material for analyses
- Written informed consent
You will not qualify if you...
- Uncontrolled comorbidities
- Infections in the endometrial cavity such as pyometra
- Presence of synchronous tumors
- Receipt of neoadjuvant treatments
- Previous radiation treatments to the pelvic area
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
"Regina Elena" National Cancer Institute
Rome, Italy, 00144
Actively Recruiting
Research Team
V
Valentina Bruno, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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