Study of Drug Absorption in Adults with Ileostomy or Colostomy Taking Psychotropic Medications or NOACs

What this Trial Is About

Researchers are studying how drugs are absorbed in patients with ostomies, focusing on psychotropic drugs and novel oral anticoagulants NOACs. These drugs absorption is not well understood in ostomy patients, as previous studies often involve only small groups or case reports. The study aims to find out if therapeutic blood levels are reached when these medications are taken orally by ileostomy and colostomy patients. This observational trial monitors drug levels by collecting blood samples during routine medical care, avoiding additional risks to participants. The study compares measured drug levels in ileostomy and colostomy patients to the therapeutic ranges defined in previous approval studies. Relevant patient data and plasma drug levels will be recorded and analyzed to evaluate absorption. Participants will be patients with an ileostomy or colostomy who have been taking specified psychotropic drugs or NOACs for at least seven days. Blood samples taken as part of regular treatment will be used to measure drug levels. The main outcome is whether therapeutic serum concentrations are achieved over an 18-month period. The study is sponsored by WiGeV Klinik Ottakring and involves no extra risks beyond routine care.

Impact on the Absorption of Drugs in Ostomy Patients