Actively Recruiting
Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen
Led by University of Chicago · Updated on 2025-12-09
200
Participants Needed
3
Research Sites
282 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the impact of ibuprofen in men with elevated serum PSA.
CONDITIONS
Official Title
Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients age between 18-80 years old with a screening PSA > 3 ng/ml being considered for additional diagnostic testing (e.g., MRI, biopsy)
- Normal digital rectal examination
- No clinical symptoms concerning acute urinary tract infection (e.g. dysuria, malodorous urine, positive urine culture)
You will not qualify if you...
- Active urinary tract infections or bacteriuria
- Known prostate cancer
- Urethral catheter within the last 6 weeks
- History of hypersensitivity or allergy to ibuprofen or NSAIDs
- Known severe chronic kidney disease: eGFR < 30 mL/min/1.73 m2
- Known history of severe liver disease (elevated AST or ALT greater than 3 times upper limit of normal)
- History of gastrointestinal bleeding or NSAIDs induced GI adverse events
- Concomitant dual-antiplatelet use or anticoagulants
- Concomitant anti-inflammatory or steroidal drugs
- Known bleeding disorder(s)
- Patients with a solitary kidney or history of a kidney transplant
- Any other medical contraindication to NSAIDs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
2
Albany Medical College
Albany, New York, United States, 12208
Actively Recruiting
3
The Pennsylvania State University at The Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
Research Team
S
Scott Eggener, MD
CONTACT
L
Leila Yazdanbakhsh, MSCI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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